Visualizing fungal infections deep in living host tissue reveals proline metabolism facilitates virulence

An international team of scientists, led by researchers from the Department of Molecular Biosciences, The Wenner-Gren Institute, SciLifeLab, Stockholm University has published in PLoS Pathogens the first successful application of two-photon intravital microscopy (IVM) to image the dynamics of fungal infections in the kidney of a living host. The study reveals that the opportunistic human fungal pathogen Candida albicans requires the ability to metabolize proline, an amino acid obtained from the host, to mount virulent infections.  Read More 

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